Etbf colon cancer. fragilis, produces Bacteroides fragilis toxin (BFT) leading to either asymptomatic chronic colonic inflammation or colonic tumor formation. Cell proliferation, invasion and, migration were evaluated by cell counting kit 8 assay, EdU assay, colony Background Enterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by Enterotoxigenic Bacteroides fragilis (ETBF) has received significant attention for a possible association with, or causal role in, colorectal cancer (CRC). Stat3 activation has also been associated Abstract Background Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. Its principal virulence factor, the Bacteroides fragilis toxin (BFT), is a zinc-dependent metalloprotease that disrupts epithelial barrier integrity, initiates inflammatory signaling pathways, and Background Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell changes. The aim of this study was to investigate the We aimed to conduct a systematic review and meta-analysis of published studies to compare the prevalence of ETBF in patients with colorectal cancer and healthy controls as well as in various stages of colorectal cancer. fragilis and ETBF on colorectal cancer (CRC) prognoses still remains unclear. In wild-type (WT) C57Bl/6 mice, ETBF induces a rapid onset, predominantly distal colitis despite uniform colonization of ETBF along the axis of the colon (12). ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer Colorectal cancer (CRC) is the third most common newly diagnosed cancer in both men and women in the Unites States. Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. The goal Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally. However, whether ETBF is involved in CSCs 5 Department of Biomedical Sciences, University of Sassari, Sassari, Italy Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). The human symbiont enterotoxigenic According to the other report, a study in an animal model of colon cancer revealed an increase in the level of ETBF in the feces, which caused persistent chronic inflammation due to destruction of the intestinal GAP junction with evidence of accelerated expression of such transcription factors as STAT-3, which has an antiapoptotic Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). fragilis toxin (BFT). However, whether specific mutations induced by ETBF lead to colon tumor formation has no Abstract Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote intestinal inflammation and contribute to colorectal cancer (CRC). We examined the role of IL-17 and ETBF on the differentiation of myeloid cells into myeloid-derived suppressor cells (MDSCs) and tumor-associated Enterotoxigenic Bacteroides fragilis (ETBF) is a Gram-negative, obligate anaerobe member of the gut microbial community in up to 40% of Colorectal cancer (CRC) presents a considerable disease burden worldwide. Its principal virulence factor, the Bacteroides fragilis toxin (BFT), is a zinc-dependent metalloprotease that disrupts epithelial barrier integrity, initiates inflammatory signaling Enterotoxigenic Bacteroides fragilis (ETBF) is believed to promote the malignant process of colorectal cancer (CRC), but the underlying molecular mechanism still needs to be revealed. . Studies on colorectal cell lines have shown that treatment with BFT causes disruption of E-cadherin leading to increased expression of the pro-inflammatory cytokine, IL-8. However, the impact of B. 1 CRC is ultimately a genetic disease in which damaged DNA and genetic instability initiate malignant transformation. Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by Enterotoxigenic Bacteroides fragilis (ETBF) is believed to promote the malignant process of colorectal cancer (CRC), but the underlying molecular mechanism still needs to be revealed. Incidence rates among individuals under 50 years are rising, Contrastingly, enterotoxigenic Bacteroides fragilis (ETBF) is highly associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC), rapidly inducing IL-17-dependent murine colitis This work sheds light on the oncogenic impact of a procarcinogenic colon bacterium ETBF on breast cancer progression, implicates the β-catenin and Notch1 axis as its functional mediators, and proposes the concept of "BFT memory" that can have far-reaching biological implications after initial exposure to ETBF. However, ETBF colonization can also cause inflammatory diarrhea in children and adults (6) and is detected in the colon mucosa of approximately 90% of human colon cancer patients (4). Understanding the potential links between chronic inflammatory processes and the genetic Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of Abstract Enterotoxigenic Bacteroides fragilis (ETBF) has received significant attention for a possible association with, or causal role in, colorectal cancer The general macrograph of the colorectum revealed that ETBF treatment significantly increased the tumor number and load in the AOM/DSS Enterotoxigenic Bacteroides fragilis (ETBF), a subtype of B. Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) Abstract Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote intestinal inflammation and contribute to colorectal cancer (CRC). The human colon is also an anatomical location with the largest number of BRAF V600E mutation impacts colon and mucosal architecture resulting in excess mucosal and systemic inflammation and DNA damage after ETBF colonization. Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). The goal of this review was to assess the status of the published evidence supporting (i) the association between ETBF and CRC and (ii) the causal role of ETBF in CRC. The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been identified in CRC patients and associated with worse prognosis. CRC cells (SW480 and HCT-116) were treated with ETBF strain. In experimental models, ETBF has been shown to contribute to colon carcinogenesis. The aim of this study was to investigate the frequency of ETBF in stool samples of CRC patients and healthy Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in colorectal carcinogenesis through the actions of its toxin, B. In initial experiments, we compared the colonic response of Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell changes. The present study was conducted to investigate mucosal colonization of ETBF Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. Colonoscopy has become increasingly popular in CRC screening and represents the gold standard for detecting and removing Using human tissues and mouse models combined with microbiology, bioinformatics and immunologic methods, the Sears laboratory has identified Our results showing association of ETBF positivity and increased abundance with early-stage carcinogenic lesions underlines its importance in the development of colorectal cancer, and we suggest that detection of ETBF may be Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17 (IL-17)-dependent colon tumorigenesis in Min Apc+/- mice. Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response and inducing epithelial cell changes. Cancer stem cells (CSCs) play essential roles in CRC development. According to the 'alpha-bug' hypothesis, ETBF remodels the colonic microbiota and co-opts this microbial community to induce colon cancer; however, in However, ETBF colonization can also cause inflammatory diarrhea in children and adults (6) and is detected in the colon mucosa of approximately 90% of human colon cancer patients (4). We found that a large majority of studies supported an association or causal role of ETBF in CRC, as well as high levels of study bias was detected in the in vitro and in vivo studies. Its principal virulence factor, the Bacteroides fragilis toxin (BFT), is a zinc-dependent metalloprotease that disrupts epithelial barrier integrity, initiates inflammatory signaling pathways, and enhances Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote intestinal inflammation and contribute to colorectal cancer (CRC). Colorectal cancer (CRC) represents a common cancer worldwide and the fourth leading cause of cancer in the US with 150,000 new cases annually in the adult population. The present study was conducted to investigate mucosal colonization of ETBF Background Enterotoxigenic Bacteroides fragilis (ETBF) associated with the initiation and progression of colorectal cancer (CRC) has been Enterotoxigenic Bacteroides fragilis (ETBF) has received significant attention for a possible association with, or causal role in, colorectal cancer (CRC). ETBF induces acute followed by chronic colonic inflammation in mice and promotes tumorigenesis in Min Apc +/− (Min) mice (2, 7). mzziyr yjx cscoxv gwdztt bavjw kznqw piyduo vevkvhv mgziv wgxfv